Tramadol hcl generic name

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This information is not country-specific. Please refer to the Indonesia prescribing information. Indications and Dosage. Oral Moderate to severe pain Adult: mg hrly. Extended-release tab: mg once or twice daily. Adult: Initially, mg followed by 50 mg every min if necessary, to a total of mg in the 1st hr including initial dose.

Thereafter, mg hrly up to a total daily dose of mg. Special Patient Group. Pharmacogenomics: Variations in CYP2D6 polymorphism occur at different frequencies among subpopulations of different ethnic or racial origin. Some individuals may be ultra-rapid metabolisers. These individuals convert tramadol into its active metabolite, O-desmethyltramadol M1 , more rapidly and completely than other people. This rapid conversion in higher than expected serum M1 levels. Analgesics which are not affected by CYP2D6 polymorphism e.

Monitor for decreased efficacy. Consider increasing the dose and if the response is still inadequate, either select alternative drug not oxycodone or codeine or be alert to symptoms of insufficient pain relief. Renal Impairment. Hepatic Impairment. Oral: Severe: Increase dosing interval to 12 hrly; Contraindicated extended-release.

Parenteral: Severe: Increase dosing interval to 12 hrly. Diazepam, diclofenac Na, flunitrazepam, glyceryl trinitrate, indometacin, midazolam, piroxicam, phenylbutazone, aciclovir, clindamycin. Not intended for narcotic withdrawal treatment. Severe renal and hepatic impairment. CYP2D6 ultra-rapid metabolisers. Special Precautions. Patients who suffer from emotional disturbance or depression, history of epilepsy or risk of seizure, head injury, increased intracranial pressure.

CYP2D6 intermediate and poor metabolisers. Renal and hepatic impairment. Pregnancy and lactation. Adverse Reactions. Resp depression, seizure, dizziness, headache, somnolence, weakness, CNS stimulation e. Patient Counseling Information. Monitoring Parameters.

Monitor pain relief, resp rate, BP, pulse rate; s of tolerance, abuse, or suicidal ideation. Symptoms: Miosis, vomiting, cold and clammy skin, resp depression, lethargy, flaccid skeletal muscle, coma, seizures, bradycardia, hypotension, cardiac arrest, cardiac collapse. Although naloxone will reverse some symptoms of overdosage, there is an increased risk of seizures. Drug Interactions. May potentiate the anti-depressant effect of norepinephrine, 5-HT agonists or lithium. Food Interaction.

Description: Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It alters perception and response to pain by binding to mu-opiate receptors in the CNS. Onset: Approx 1 hr. Duration: 9 hr. Pharmacokinetics: Absorption: Readily absorbed from the GI tract. Distribution: Widely distributed. Crosses the placenta and enters breast milk.

Metabolism: Extensive hepatic first-pass metabolism. Excretion: Via urine as metabolites. Elimination half-life: Approx 6 hr. MIMS Class. Analgesics Opioid. ATC Classification. N02AX02 - tramadol ; Belongs to the class of other opioids. Used to relieve pain. Lexicomp Online. Hudson, Ohio. Bethesda, MD. Buckingham R ed. Tramadol Hydrochloride. Martindale: The Complete Drug Reference [online].

Pharmaceutical Press. Source: U. National Library of Medicine. Wickersham RM. Facts and Comparisons [online]. Louis, MO. Disclaimer: This information is independently developed by MIMS based on Tramadol from various references and is provided for your reference only.

Therapeutic uses, prescribing information and product availability may vary between countries. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. All rights reserved. Powered by MIMS. Available Brands. Other Known Brands. Related Diseases. Already a member? in. Indications and Dosage Oral Moderate to severe pain Adult: mg hrly.

Parenteral Postoperative pain Adult: Initially, mg followed by 50 mg every min if necessary, to a total of mg in the 1st hr including initial dose. Special Patient Group Pharmacogenomics: Variations in CYP2D6 polymorphism occur at different frequencies among subpopulations of different ethnic or racial origin.

Hepatic Impairment Oral: Severe: Increase dosing interval to 12 hrly; Contraindicated extended-release. Administration May be taken with or without food. Incompatibility Diazepam, diclofenac Na, flunitrazepam, glyceryl trinitrate, indometacin, midazolam, piroxicam, phenylbutazone, aciclovir, clindamycin.

Special Precautions Patients who suffer from emotional disturbance or depression, history of epilepsy or risk of seizure, head injury, increased intracranial pressure. Adverse Reactions Resp depression, seizure, dizziness, headache, somnolence, weakness, CNS stimulation e. Patient Counseling Information May impair ability to drive or operate machinery. Monitoring Parameters Monitor pain relief, resp rate, BP, pulse rate; s of tolerance, abuse, or suicidal ideation. Overdosage Symptoms: Miosis, vomiting, cold and clammy skin, resp depression, lethargy, flaccid skeletal muscle, coma, seizures, bradycardia, hypotension, cardiac arrest, cardiac collapse.

Action Description: Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. Protect from light.

Tramadol hcl generic name

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